"Crescent Disease" is caused by environmental pollution.The government then sets up a Relief Committee for Crescent Disease. Fox, one of the doctors forming the Relief Committee, asks Black Jack to participate as a special contributor. Black Jack and Pinoko meet a girl named Tsukiko in the Crescent Gulf. Despite her disease, Tsukiko has a positive attitude toward life. Black Jack starts to feel himself drawn toward her way of living, as which is based on freedom and instinct.