'New Heart' is about the growth and sufferings of the heart surgeons who work in the department of Thoracic and Cardiovascular Surgery. Two residents struggle through the demanding hours of residency to become a great cardiac specialist. Lee Eun Sung who graduated from a newly established medical school is looked down upon by people at the hospital. Nam Hye Suk, a straight A student from the medical school, is a fundamentalist with a great pride. The two get close as they become apprenticed to Dr. Choi Kang Gook who became the new head of the department of Thoracic and Cardiovascular Surgery.