Jung-woo is a neurosurgeon who successfully developed the world's first bioengineering study. Yu-kyung is a plastic surgeon and she is slowly but surely building her career. Then one day, she experiences a mysterious incident. Her hand is severed, but Jung-woo quickly does a surgery to attach her hand. It looks like the operation went well, however...Incomprehensible, mysterious incidents begin to take place around Yu-kyung. An unstoppable horror begins to engulf everyone. It's the unique medical horror movie "Black Hand".